Tuesday, September 23, 2014

Viruses attach to lymphocytes that have a receptor protein called CD4, which is contained in the ou

HIV / AIDS | Monocytes's Weblog
Infection with HIV (Human Immunodeficiency Virus) is an infection by any one of the two types of viruses that progressively destroy the white blood cells called lymphocytes, causes AIDS (Acquired Immunodeficiency Syndrome) and other diseases as a result of immune disorders.
In early 1980, the researchers found a sudden increase of 2 types of illness among homosexuals in America. Both diseases were Kaposi's sarcoma (a rare form of cancer) and pneumonia pneumokista (a type of pneumonia that occurs only in people e631 with immune system disorders).
The failure of the immune system that lead to the emergence of two types of this rare disease now known as AIDS. The failure of the immune system are also found in users of illicit drugs are injected, hemophiliacs, blood transfusion recipients and bisexual men. Some time later this syndrome also began to occur in heterosexuals who are not drug users, hemophiliacs not and do not accept blood transfusions.
AIDS has become an epidemic in the United States with more than 500,000 people infected and 300,000 died until October 1995 the WHO estimates that 30-40 million people worldwide will be infected with HIV in 2000 CAUSE
There are 2 types of the virus that causes AIDS, namely e631 HIV-1 and HIV-2. HIV-1 is most prevalent in the western region, Europe, Asia and Central Africa, South and East. HIV-2 is found primarily in West Africa. CLINICAL COURSE
Infection to occur, the virus must enter the cell, in this case the white blood cells called lymphocytes. Viral genetic material is inserted e631 into the DNA of infected cells. Inside the cell, the virus multiply and eventually destroy the cell and release of new viral particles. New virus particles then infect other lymphocytes and destroy it.
Viruses attach to lymphocytes that have a receptor protein called CD4, which is contained in the outer membrane. Cells that have CD4 receptors are usually called e631 CD4 + cells or helper T lymphocytes. Activate e631 helper T lymphocyte function and regulate other cells of the immune system (such as B lymphocytes, macrophages and cytotoxic T lymphocytes), all of which help destroy malignant cells and foreign organisms. HIV infection destroys T helper lymphocytes, causing weakness in the body's system to protect itself against infections and cancer.
A person infected with HIV will lose helper T lymphocytes through 3 stages for several months or years: A healthy person has a CD4 lymphocyte much as 800-1300 cells / mL of blood. In the first few months after infection with HIV, the numbers decreased by 40-50%. During these months the patient can transmit HIV to others because many virus particles present in the blood. Although the body tries to fight the virus, but the body is not able to relieve e631 the infection. After about 6 months, the number of virus particles in the blood reaches a stable level, which is different in every patient. Destruction of CD4 + cells and the transmission of disease to others continues. High levels of virus particles and CD4 + lymphocyte levels were low assist physicians in determining people at high risk of suffering from AIDS. 1-2 years before the onset of AIDS, CD4 + lymphocyte count is usually decreased dramatically. If the level reaches 200 cells / mL of blood, the patient becomes e631 susceptible to infection.
HIV infection also causes disturbances in the function of B lymphocytes (lymphocytes which produce antibodies) and often causes e631 excessive production of antibodies. These antibodies are mainly directed against e631 HIV and infections experienced by patients, but these antibodies are not much help in the fight against various opportunistic infections e631 in AIDS. At the same time, the destruction of CD4 + lymphocytes e631 by virus cause a reduction in the immune system's ability to recognize organisms and new targets to be attacked.
HIV transmission occurs through contact with body fluids containing infected cells or virus particles. The meaning here is body fluids blood, semen, e631 vaginal secretions, cerebrospinal fluid, and breast milk. In smaller concentrations, the virus is also present in tears, saliva and water kemihi.
HIV is transmitted through the following ways: Sexual relationships e631 with patients, in which the mucous membranes of the mouth, vagina or rectum in direct contact with body fluids contaminated injections or infusion of contaminated blood, as occurs in a blood transfusion, the use of needles jointly or unintentionally scratched by a needle contaminated with HIV virus transfer of the virus from an infected mother to her child before or during birth or through ASI.Kemungkinan infected by HIV increases if the skin

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