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Monocytes (English: monocytes, mononuclear) are white blood groups that are part of the immune system. Monocytes can be recognized from the color of their nuclei. In the event of inflammation, monocytes: migrate to the location of the infection of macrophages and DC cells to replace damaged or migrated, by dividing or transformed into one of the cells. Monocytes are produced in the bone marrow from stem cells called isopropyl alcohol monoblas haematopoetik. Half the amount of production isopropyl alcohol is stored in the spleen on the pulp. [1] Monocytes isopropyl alcohol circulate in the bloodstream by plasma ratio of 3-5% for one to three days, then migrate to tissues throughout the body. Once on the network, will be mature monocytes and macrophages differentiated into several types, dendritic cells and osteoclasts. [2] Generally there are two groupings of macrophages by activation of monocytes, macrophages results that hormone activation of M-CSF and GM-CSF hormone. M-CSF macrophages have a larger cytoplasm, higher phagocytic capacity and is more resistant to vesicular stomatitis virus infection. In contrast, GM-CSF macrophages are more cytotoxic against isopropyl alcohol cells resistant to TNF type cytokines, MHC class II expression has more, and secretion of PGE are more numerous and regular. After that, derivative type macrophages will be further determined by other stimulants such as hormones kind of class interferon and TNF class. Hormone stimulation type cytokines GM-CSF and IL-4 activates monocytes and macrophages to become dendritic cells.
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